MicroRNAs: Game Changers in the Regulation of ?-Synuclein in Parkinson's Disease.
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ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC6525811 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
MicroRNAs: Game Changers in the Regulation of <i>α</i>-Synuclein in Parkinson's Disease.
Parkinson's disease 20190502
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates of <i>α</i>-synuclein (<i>α</i>-syn). An imbalance between the rates of <i>α</i>-syn synthesis, aggregation, and clearance can result in abnormal <i>α</i>-syn levels and contribute to the pathogenesis of PD. MicroRNAs (miRNAs) are endogenous single-stranded noncoding ...[more]
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