Ontology highlight
ABSTRACT:
SUBMITTER: Turanov AA
PROVIDER: S-EPMC6526074 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Turanov Anton A AA Lo Agnes A Hassler Matthew R MR Makris Angela A Ashar-Patel Ami A Alterman Julia F JF Coles Andrew H AH Haraszti Reka A RA Roux Loic L Godinho Bruno M D C BMDC Echeverria Dimas D Pears Suzanne S Iliopoulos Jim J Shanmugalingam Renuka R Ogle Robert R Zsengeller Zsuzsanna K ZK Hennessy Annemarie A Karumanchi S Ananth SA Moore Melissa J MJ Khvorova Anastasia A
Nature biotechnology 20181119
Preeclampsia is a placentally induced hypertensive disorder of pregnancy that is associated with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of preterm preeclampsia result from excess circulating soluble vascular endothelial growth factor receptor FLT1 (sFLT1 or sVEGFR1) of placental origin. Here we identify short interfering RNAs (siRNAs) that selectively silence the three sFLT1 mRNA isoforms primarily responsible for placental overexpression of sFLT1 wit ...[more]