Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway.

ABSTRACT:

Background

Previous evidence has indicated CMP-Neu5Ac hydroxylase (Cmah) disruption inducesaging-related hearing loss (AHL). However, its function mechanisms remain unclear. This study was to explore the mechanisms of AHL by using microarray analysis in the Cmah deficiency animal model.

Methods

Microarray dataset GSE70659 was available from the Gene Expression Omnibus database, including cochlear tissues from wild-type and Cmah-null C57BL/6J mice with old age (12 months, n = 3). Differentially expressed genes (DEGs) were identified using the Linear Models for Microarray data method and a protein-protein interaction (PPI) network was constructed using data from the Search Tool for the Retrieval of Interacting Genes database followed by module analysis. Kyoto Encycloped

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6526899 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature