Unknown

Dataset Information

0

Prevalence and Impact of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living in the US and Canada.


ABSTRACT: Background:Patients with chronic hepatitis B virus (HBV) may experience spontaneous biochemical flares of liver disease activity. This study aimed to determine (i) the prevalence of prior and possible acute hepatitis E virus (HEV) infection among persons with chronic HBV and (ii) whether HEV infection is associated with liver disease flares among persons with chronic HBV. Methods:Serum from a random sample of 600 adults in the Hepatitis B Research Network Cohort Study was tested for HEV RNA and anti-HEV IgM and IgG. Logistic regression models were used to estimate crude and adjusted odds ratios of anti-HEV prevalence for participant characteristics. Results:Anti-HEV IgG and IgM seroprevalence was 28.5% and 1.7%, respectively. No participants had detectable HEV RNA. Of the 10 anti-HEV IgM+ participants, only 1 had elevated serum ALT at seroconversion. The odds of anti-HEV seropositivity (IgG+ or IgM+) were higher in older participants, males, Asians, less educated people, and those born outside the United States and Canada. Conclusions:Acute HEV infection is a rare cause of serum ALT flares among persons with chronic HBV. The high seroprevalence of anti-HEV IgG among the chronic HBV patients is strongly associated with various demographic factors in this largely Asian American cohort.

SUBMITTER: McGivern DR 

PROVIDER: S-EPMC6527087 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prevalence and Impact of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living in the US and Canada.

McGivern David R DR   Lin Hsing-Hua S HS   Wang Junyao J   Benzine Tiffany T   Janssen Harry L A HLA   Khalili Mandana M   Lisker-Melman Mauricio M   Fontana Robert J RJ   Belle Steven H SH   Fried Michael W MW  

Open forum infectious diseases 20190409 5


<h4>Background</h4>Patients with chronic hepatitis B virus (HBV) may experience spontaneous biochemical flares of liver disease activity. This study aimed to determine (i) the prevalence of prior and possible acute hepatitis E virus (HEV) infection among persons with chronic HBV and (ii) whether HEV infection is associated with liver disease flares among persons with chronic HBV.<h4>Methods</h4>Serum from a random sample of 600 adults in the Hepatitis B Research Network Cohort Study was tested f  ...[more]

Similar Datasets

| S-EPMC8453838 | biostudies-literature
| S-EPMC8491712 | biostudies-literature
| S-EPMC3787685 | biostudies-literature
| S-EPMC3294504 | biostudies-literature
| S-EPMC4336227 | biostudies-literature
| S-EPMC6956563 | biostudies-literature
| S-EPMC3073667 | biostudies-literature
| S-EPMC4735500 | biostudies-other
| S-EPMC8034296 | biostudies-literature
| S-EPMC11356368 | biostudies-literature