Ontology highlight
ABSTRACT:
SUBMITTER: Lilis I
PROVIDER: S-EPMC6527299 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lilis Ioannis I Ntaliarda Giannoula G Papaleonidopoulos Vassilios V Giotopoulou Georgia A GA Oplopoiou Maria M Marazioti Antonia A Spella Magda M Marwitz Sebastian S Goldmann Torsten T Bravou Vasiliki V Giopanou Ioanna I Stathopoulos Georgios T GT
Oncoimmunology 20190411 7
Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their functional role has not been investigated <i>in vivo</i>. For this, we applied three mouse models of <i>KRAS-</i>mutant LADC to two different MC-deficient mouse strains (<i>cKit</i><sup>Wsh</sup> and <i>Cpa3.Cre</i>). Moreover, we derived MC gene signatures from murine bone marrow-derived MC and used them to interrogate five human cohorts of LADC patients. Tumor-free <i>cKit</i><sup>Wsh</sup> and <i>Cpa3. ...[more]