The Extracellular Matrix Modulates the Metastatic Journey.
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ABSTRACT:
SUBMITTER: Kai F
PROVIDER: S-EPMC6527347 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
The Extracellular Matrix Modulates the Metastatic Journey.
Kai FuiBoon F Drain Allison P AP Weaver Valerie M VM
Developmental cell 20190501 3
The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matrix regulates metastasis by fostering tumor cell invasion into the stroma and migration toward the vasculature. We describe the role of the tumor matrix in cancer cell intravasation and vascular dissemination. We examine the impact of the matrix on di ...[more]
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