Ontology highlight
ABSTRACT:
SUBMITTER: Rohozkova J
PROVIDER: S-EPMC6527391 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Rohožková Jana J Hůlková Lenka L Fukalová Jana J Flachs Petr P Hozák Pavel P Hozák Pavel P
Nucleus (Austin, Tex.) 20191201 1
During meiosis, homologous chromosomes undergo a dramatic movement in order to correctly align. This is a critical meiotic event but the molecular properties of this 'chromosomal dance' still remainunclear. We identified DEB-1 - an orthologue of mammalian vinculin - as a new component of the mechanistic modules responsible for attaching the chromosomes to the nuclear envelope as apart of the LINC complex. In early meiotic nuclei of C. elegans, DEB-1 is localized to the nuclear periphery and alon ...[more]