Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC6527444 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chen Xiaohui X Cao Xihua X Tu Xuhuang X Alitongbieke Gulimiran G Xia Zebin Z Li Xiaotong X Chen Ziwen Z Yin Meimei M Xu Dan D Guo Shangjie S Li Zongxi Z Chen Liqun L Zhang Xindao X Xu Dingyu D Gao Meichun M Liu Jie J Zeng Zhiping Z Zhou Hu H Su Ying Y Zhang Xiao-Kun XK
Molecular cancer therapeutics 20190329 5
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic molecule. Nur77 posttranslational modification such as phosphorylation has been shown to induce Nur77 translocation from the nucleus to mitochondria. However, small molecules that can bind directly to Nur77 to trigger its mitochondrial localization and Bcl-2 interaction r ...[more]