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As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

ABSTRACT: Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

SUBMITTER: Blice-Baum AC

PROVIDER: S-EPMC6527462 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Blice-Baum Anna C AC Guida Maria Clara MC Hartley Paul S PS Adams Peter D PD Bodmer Rolf R Cammarato Anthony A

Biochimica et biophysica acta. Molecular basis of disease 20181127 7

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or ...[more]

PMID: 30496794

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