Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC6527555 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zhang Jianhua J Tao Ran R Campbell Katherine F KF Carvalho Juliana L JL Ruiz Edward C EC Kim Gina C GC Schmuck Eric G EG Raval Amish N AN da Rocha André Monteiro AM Herron Todd J TJ Jalife José J Thomson James A JA Kamp Timothy J TJ
Nature communications 20190520 1
Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The limited availability of human CFs from native heart impedes investigations of CF biology and their role in disease. Human pluripotent stem cells (hPSCs) provide a highly renewable and genetically defined cell source, but efficient methods to generate CFs from hPSCs have not been described. Here, we show differentiation of hPSCs using sequential modulation of Wnt and FGF signaling to generate second ...[more]