Ontology highlight
ABSTRACT:
SUBMITTER: Shehata M
PROVIDER: S-EPMC6527562 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Shehata Mona M Kim Hyeyeon H Vellanki Ravi R Waterhouse Paul D PD Mahendralingam Mathepan M Casey Alison E AE Koritzinsky Marianne M Khokha Rama R
Communications biology 20190520
The heterogeneity of breast cancer makes current therapies challenging. Metformin, the anti-diabetic drug, has shown promising anti-cancer activities in epidemiological studies and breast cancer models. Yet, how metformin alters the normal adult breast tissue remains elusive. We demonstrate metformin intake at a clinically relevant dose impacts the hormone receptor positive (HR+) luminal cells in the normal murine mammary gland. Metformin decreases total cell number, progenitor capacity and spec ...[more]