Ontology highlight
ABSTRACT:
SUBMITTER: Rao-Ruiz P
PROVIDER: S-EPMC6527697 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature communications 20190520 1
Sparse populations of neurons in the dentate gyrus (DG) of the hippocampus are causally implicated in the encoding of contextual fear memories. However, engram-specific molecular mechanisms underlying memory consolidation remain largely unknown. Here we perform unbiased RNA sequencing of DG engram neurons 24 h after contextual fear conditioning to identify transcriptome changes specific to memory consolidation. DG engram neurons exhibit a highly distinct pattern of gene expression, in which CREB ...[more]