Ontology highlight
ABSTRACT:
SUBMITTER: Ballard C
PROVIDER: S-EPMC6527908 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ballard Clive C Atri Alireza A Boneva Neli N Cummings Jeffrey L JL Frölich Lutz L Molinuevo José Luis JL Tariot Pierre N PN Raket Lars Lau LL
Alzheimer's & dementia (New York, N. Y.) 20190520
<h4>Introduction</h4>Heterogeneity of outcomes in Alzheimer's disease (AD) clinical trials necessitates large sample sizes and contributes to study failures. This analysis determined whether mild-to-moderate AD populations could be enriched for cognitive decline based on apolipoprotein (<i>APOE</i>) ε4 genotype, family history of AD, and amyloid abnormalities.<h4>Methods</h4>Modeling estimated the number of randomized patients needed to detect a 2-point treatment difference on the AD Assessment ...[more]