Ontology highlight
ABSTRACT:
SUBMITTER: Carreras J
PROVIDER: S-EPMC6528140 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Carreras Joaquim J Lopez-Guillermo Armando A Kikuti Yara Yukie YY Itoh Johbu J Masashi Miyaoka M Ikoma Haruka H Tomita Sakura S Hiraiwa Shinichiro S Hamoudi Rifat R Rosenwald Andreas A Leich Ellen E Martinez Antonio A Roncador Giovanna G Villamor Neus N Colomo Lluis L Perez Patricia P Tsuji Noriko M NM Campo Elias E Nakamura Naoya N
Journal of clinical and experimental hematopathology : JCEH 20190101 1
The microenvironment influences the behavior of follicular lymphoma (FL) but the specific roles of the immunomodulatory BTLA and TNFRSF14 (HVEM) are unknown. Therefore, we examined their immunohistochemical expression in the intrafollicular, interfollicular and total histological compartments in 106 FL cases (57M/49F; median age 57-years), and in nine relapsed-FL with transformation to DLBCL (tFL). BTLA expression pattern was of follicular T-helper cells (TFH) in the intrafollicular and of T-cel ...[more]