Ontology highlight
ABSTRACT:
SUBMITTER: She P
PROVIDER: S-EPMC6528602 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
She Pengfei P Luo Zhen Z Chen Lihua L Wu Yong Y
MicrobiologyOpen 20180905 5
Microbial biofilms are formed in a variety of clinical situations and increase antibiotic resistance of the pathogen by almost ~1,000 times. The effect of levofloxacin (OFLX) on the biofilms of Pseudomonas aeruginosa strain PAO1 and the clinical isolates was investigated by crystal violet staining and confocal laser scanning microscope. The transcriptional alteration in the PAO1 biofilms upon OFLX treatment was also analyzed by RNA sequencing (RNA-seq). We found that while OFLX significantly inh ...[more]