Ontology highlight
ABSTRACT:
SUBMITTER: Dhar SS
PROVIDER: S-EPMC6528658 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Dhar Shilpa S SS Zhao Dongyu D Lin Tao T Gu Bingnan B Pal Khusboo K Wu Sarah J SJ Alam Hunain H Lv Jie J Yun Kyuson K Gopalakrishnan Vidya V Flores Elsa R ER Northcott Paul A PA Rajaram Veena V Li Wei W Shilatifard Ali A Sillitoe Roy V RV Chen Kaifu K Lee Min Gyu MG
Molecular cell 20180531 5
Super-enhancers are large clusters of enhancers that activate gene expression. Broad trimethyl histone H3 lysine 4 (H3K4me3) often defines active tumor suppressor genes. However, how these epigenomic signatures are regulated for tumor suppression is little understood. Here we show that brain-specific knockout of the H3K4 methyltransferase MLL4 (a COMPASS-like enzyme, also known as KMT2D) in mice spontaneously induces medulloblastoma. Mll4 loss upregulates oncogenic Ras and Notch pathways while d ...[more]