Ontology highlight
ABSTRACT:
SUBMITTER: Massart R
PROVIDER: S-EPMC6528794 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Massart R R Suderman M M Provencal N N Yi C C Bennett A J AJ Suomi S S Szyf M M
Neuroscience 20140319
5-Hydroxymethylcytosine (5hmC) is abundant in the brain, suggesting an important role in epigenetic control of neuronal functions. In this paper, we show that 5hmC and 5-methylcytosine (5mC) levels are coordinately distributed in gene promoters of the rhesus macaque prefrontal cortex. Although promoter hydroxymethylation and methylation are overall negatively correlated with expression, a subset of highly expressed genes involved in specific cerebral functions is associated with high levels of 5 ...[more]