The Signature of Maternal Social Rank in Placenta Deoxyribonucleic Acid Methylation Profiles in Rhesus Monkeys.
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ABSTRACT:
SUBMITTER: Massart R
PROVIDER: S-EPMC6528796 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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The Signature of Maternal Social Rank in Placenta Deoxyribonucleic Acid Methylation Profiles in Rhesus Monkeys.
Massart Renaud R Suderman Matthew J MJ Nemoda Zsofia Z Sutti Sheila S Ruggiero Angela M AM Dettmer Amanda M AM Suomi Stephen J SJ Szyf Moshe M
Child development 20161014 3
The effects of social status on human health can be modeled in captive cohorts of nonhuman primates. This study shows that maternal social rank is associated with broad changes in DNA methylation in placentae of rhesus monkeys (N = 10). Differentially methylated genes between social ranks are enriched in signaling pathways playing major roles in placenta physiology. Moreover, the authors found significant overlaps with genes whose expression was previously associated with social rank in adult rh ...[more]
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