Ontology highlight
ABSTRACT:
SUBMITTER: Nixon-Abell J
PROVIDER: S-EPMC6528812 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nixon-Abell Jonathon J Obara Christopher J CJ Weigel Aubrey V AV Li Dong D Legant Wesley R WR Xu C Shan CS Pasolli H Amalia HA Harvey Kirsten K Hess Harald F HF Betzig Eric E Blackstone Craig C Lippincott-Schwartz Jennifer J
Science (New York, N.Y.) 20161027 6311
The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle that plays crucial roles in numerous cellular functions. We used emerging superresolution imaging technologies to clarify the morphology and dynamics of the peripheral ER, which contacts and modulates most other intracellular organelles. Peripheral components of the ER have classically been described as comprising both tubules and flat sheets. We show that this system consists almost exclusively of tubules at varying den ...[more]