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Regulation and functions of MicroRNA-149 in human cancers.

ABSTRACT: MicroRNAs are small non-coding RNAs that play critical roles in the regulatory mechanisms involving cell differentiation, proliferation, apoptosis and tumorigenesis. Recent research efforts have been conducted to apply these discoveries into clinical functions, including the early diagnosis and therapeutic outcome of patients with cancer. Previous studies have shown that microRNA-149 (miR-149) is dysregulated in various human cancers and exerts its effects on tumorigenesis and tumour progression. In this review, we summarized the potential roles of miR-149 dysregulation and its target genes during tumorigenesis and clinical treatment of human cancers.

SUBMITTER: Zhi Y

PROVIDER: S-EPMC6528861 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Regulation and functions of MicroRNA-149 in human cancers.

Zhi Yingru Y Zhou Hao H Mubalake Abudoureyimu A Chen Ying Y Zhang Bei B Zhang Kai K Chu Xiaoyuan X Wang Rui R

Cell proliferation 20180712 5

MicroRNAs are small non-coding RNAs that play critical roles in the regulatory mechanisms involving cell differentiation, proliferation, apoptosis and tumorigenesis. Recent research efforts have been conducted to apply these discoveries into clinical functions, including the early diagnosis and therapeutic outcome of patients with cancer. Previous studies have shown that microRNA-149 (miR-149) is dysregulated in various human cancers and exerts its effects on tumorigenesis and tumour progression ...[more]

PMID: 29999552

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