Unknown

Dataset Information

0

Duration of frequent or severe respiratory tract infection in adults before diagnosis of IgG subclass deficiency.


ABSTRACT: Many adults with IgG subclass deficiency (IgGSD) experience long intervals of frequent/severe respiratory tract infection before IgGSD diagnosis, but reasons for delays in IgGSD diagnoses are incompletely understood. We performed a retrospective study of 300 white adults (ages ?18 y) with IgGSD including frequency analyses of age at IgGSD diagnosis, duration of frequent/severe respiratory tract infection before IgGSD diagnosis, and age at onset of frequent/severe infection (calculated). We performed multivariable regressions on age at diagnosis, infection duration, and age at infection onset using these variables, as appropriate: sex; age at diagnosis; diabetes; autoimmune condition(s); atopy; allergy; corticosteroid use; body mass index; serum immunoglobulin isotype levels; blood lymphocyte subsets; three IgGSD-associated human leukocyte antigen-A and -B haplotypes; and referring physician specialties. Mean age at diagnosis was 50 ± 12 (standard deviation) y (median 50 y (range 19-79)). There were 247 women (82.3%). Mean infection duration at IgGSD diagnosis was 12 ± 13 y (median 7 y (range 1-66)). Mean age at infection onset was 38 ± 16 y (median 38 y (range 4, 76)). Age at infection onset was ?18 y in 95.7% of subjects. Regressions on age at diagnosis and infection duration revealed no significant associations. Regression on age at infection onset revealed one positive association: age at diagnosis (p <0.0001). We conclude that the median duration of frequent/severe respiratory tract infection in adults before IgGSD diagnosis was 7 y. Older adults may be diagnosed to have IgGSD after longer intervals of infection than younger adults. Duration of frequent/severe respiratory tract infection before IgGSD diagnosis was not significantly associated with routine clinical and laboratory variables, including referring physician specialties.

SUBMITTER: Barton J 

PROVIDER: S-EPMC6528998 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

altmetric image

Publications

Duration of frequent or severe respiratory tract infection in adults before diagnosis of IgG subclass deficiency.

Barton James J   Barton Clayborn C   Bertoli Luigi L  

PloS one 20190521 5


Many adults with IgG subclass deficiency (IgGSD) experience long intervals of frequent/severe respiratory tract infection before IgGSD diagnosis, but reasons for delays in IgGSD diagnoses are incompletely understood. We performed a retrospective study of 300 white adults (ages ≥18 y) with IgGSD including frequency analyses of age at IgGSD diagnosis, duration of frequent/severe respiratory tract infection before IgGSD diagnosis, and age at onset of frequent/severe infection (calculated). We perfo  ...[more]

Similar Datasets

| S-EPMC7840874 | biostudies-literature
| S-EPMC8353875 | biostudies-literature
| S-EPMC7553271 | biostudies-literature
| S-EPMC3513749 | biostudies-literature
| S-EPMC4830719 | biostudies-literature
| S-EPMC8198960 | biostudies-literature
| S-EPMC5603481 | biostudies-literature
| S-EPMC3327478 | biostudies-literature
| S-EPMC7995275 | biostudies-literature
| S-EPMC7555090 | biostudies-literature