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CCAT2: A novel oncogenic long non-coding RNA in human cancers.

ABSTRACT: Colon cancer-associated transcript 2 (CCAT2) was originally identified as an oncogenic long non-coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT2 has been increasingly demonstrated in human cancers. In this connection, CCAT2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT2 in human malignancies.

SUBMITTER: Xin Y

PROVIDER: S-EPMC6529071 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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CCAT2: A novel oncogenic long non-coding RNA in human cancers.

Xin Yu Y Li Zheng Z Zheng Heyi H Chan Matthew T V MTV Ka Kei Wu William W

Cell proliferation 20170228 3

Colon cancer-associated transcript 2 (CCAT2) was originally identified as an oncogenic long non-coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT2 has been increasingly demonstrated in human cancers. In this connection, CCAT2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting ...[more]

PMID: 28244168

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