Ontology highlight
ABSTRACT:
SUBMITTER: Koay HF
PROVIDER: S-EPMC6529461 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Koay Hui-Fern HF Gherardin Nicholas A NA Xu Calvin C Seneviratna Rebecca R Zhao Zhe Z Chen Zhenjun Z Fairlie David P DP McCluskey James J Pellicci Daniel G DG Uldrich Adam P AP Godfrey Dale I DI
Nature communications 20190521 1
Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like molecule, MR1. Whether MAIT cell development depends on this invariant TCR-α chain is unclear. Here we generate Traj33-deficient mice and show that they are highly depleted of MAIT cells; however, a residual population remains and can respond to exogenous antigen in vitro or pulmonary Legionella challenge in vivo. These residual cells include some that express Trav1<sup> ...[more]