Ontology highlight
ABSTRACT:
SUBMITTER: Zaitsev AV
PROVIDER: S-EPMC6529478 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zaitsev Aleksandr V AV Martinov Michael V MV Vitvitsky Victor M VM Ataullakhanov Fazoil I FI
Scientific reports 20190521 1
Folate metabolism in mammalian cells is essential for multiple vital processes, including purine and pyrimidine synthesis, histidine catabolism, methionine recycling, and utilization of formic acid. It remains unknown, however, whether these processes affect each other via folate metabolism or can function independently based on cellular needs. We addressed this question using a quantitative mathematical model of folate metabolism in rat liver cytoplasm. Variation in the rates of metabolic proce ...[more]