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The role of soil and house dust physicochemical properties in determining the post ingestion bioaccessibility of sorbed polychlorinated biphenyls.

ABSTRACT: Ingestion of soils and house dusts is an important pathway for children's exposure to sorbed organic pollutants such as polychlorinated biphenyls (PCBs). To reduce the uncertainty of the exposure estimates, it is important to understand the extent to which chemicals desorb and become bioaccessible following ingestion. In this study we use a three compartment in vitro digestive system to model the role of soil and house dust physicochemical properties on the post ingestion bioaccessibility of PCBs. Matched pairs (n?=?37) of soil and dust were characterized for percent carbon and nitrogen, pH, moisture content, and particle size distribution. They were then fortified with a mixture of 18 PCBs and processed through the assay. The percent bioaccessibility of each PCB was calculated, then modeled using individual PCB log Kow values and the soil and dust properties. The bioaccessibility of the PCBs in soil (x??=?65?±?16%) was greater (p?

SUBMITTER: Shen H

PROVIDER: S-EPMC6529950 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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The role of soil and house dust physicochemical properties in determining the post ingestion bioaccessibility of sorbed polychlorinated biphenyls.

Shen Haitao H Li Weiwei W Graham Stephen E SE Starr James M JM

Chemosphere 20181031

Ingestion of soils and house dusts is an important pathway for children's exposure to sorbed organic pollutants such as polychlorinated biphenyls (PCBs). To reduce the uncertainty of the exposure estimates, it is important to understand the extent to which chemicals desorb and become bioaccessible following ingestion. In this study we use a three compartment in vitro digestive system to model the role of soil and house dust physicochemical properties on the post ingestion bioaccessibility of PCB ...[more]

PMID: 30391787

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Project description:Soils are sorbents for many organic compounds and children consume relatively large amounts of soil. To improve the estimated health risks from this exposure pathway, we examined the role of co-ingested foods in determining the post-ingestion bioaccessibility (mobilization) of 18 polychlorinated biphenyls (PCBs) sorbed to 10 characterized soils. The bioaccessibility test system (DIN 19738, 2004) was an in vitro, 3-compartment, digestive tract containing salts, protein, and bile. Each soil was fortified with PCBs, then, digestive fluids appropriate to each compartment, were added sequentially. Next, digestive fluid and soil were seperated and PCB concentrations in both media were measured. This complete test system was then reduced to assess contributions of individual endogenous digestive fluid constituents (water, salts, pancreatin, bile, and mucin) and representative foods: protein (bovine serum albumin (BSA)), sugar (glucose), and fat (oleic acid). Then, the influence of increasing concentrations of BSA, glucose, and oleic acid was evaluated (individually) complete test systems. In a subset of the samples, solid phase microextraction (SPME) was used to measure freely dissolved PCBs. Across all treatments, percent soil organic carbon was the most influential bioaccessibility determinant, accounting for ?87% of the explained variation. When evaluated individually, pancreatin, mucin, BSA, bile, and oleic acid each effectively increased PCB bioaccessibility and reduced freely dissolved PCB concentrations. This suggests competitive sorption of PCBs by organic constituents of the digestive constituents. Without sink material, intra-PCB mobilization differences were observed as freely dissolved PCB concentrations inversely correlated (p < 0.05) with their respective log Kow's. When added to the complete digestive fluid, increasing oleic acid mass increased PCB bioaccessibility (p < 0.05), while adding more BSA or glucose did not (p > 0.05). This indicates that fat intake may be the sole consideration needed when modeling dietary contributions to bioaccessibility of soil sorbed PCBs.

Dataset Information

The role of soil and house dust physicochemical properties in determining the post ingestion bioaccessibility of sorbed polychlorinated biphenyls.

Publications

The role of soil and house dust physicochemical properties in determining the post ingestion bioaccessibility of sorbed polychlorinated biphenyls.

Similar Datasets

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