Ontology highlight
ABSTRACT: Objective
To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.Design
Prospective parallel randomised controlled open-label superiority trial.Setting
76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017.Participants
952 adults randomised within the first 72?hours of a herpes simplex labialis episode.Interventions
Random assignment 1:1 to either 5% aciclovir cream or medical grade kanuka honey (90%)/glycerine (10%) cream, both applied five times daily.Outcome measures
The primary outcome was time from randomisation to return to normal skin (stage 7). Secondary outcomes included time from randomisation to stage 4 (open wound), time from stage 4 to 7, maximal pain, time to pain resolution and treatment acceptability.Results
Primary outcome variable: Kaplan-Meier-based estimates (95%?CI) for the median time in days for return to normal skin were 8 (8 to 9) days for aciclovir and 9 (8 to 9) for honey; HR (95%?CI) 1.06 (0.92 to 1.22), p=0.56. There were no statistically significant differences between treatments for all secondary outcome variables. No related serious adverse events were reported.Conclusion
There was no evidence of a difference in efficacy between topical medical grade kanuka honey and 5% aciclovir in the pharmacy-based treatment of herpes simplex labialis.Trial registration number
ACTRN12615000648527;Post-results.
SUBMITTER: Semprini A
PROVIDER: S-EPMC6530412 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
BMJ open 20190514 5
<h4>Objective</h4>To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.<h4>Design</h4>Prospective parallel randomised controlled open-label superiority trial.<h4>Setting</h4>76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017.<h4>Participants</h4>952 adults randomised within the first 72 hours of a herpes simplex labialis episode.<h4>Interventions</h4>Random assignment 1:1 to either 5% aciclovi ...[more]