MDM2, MDM2-C, and mutant p53 expression influence breast cancer survival in a multiethnic population.
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ABSTRACT:
SUBMITTER: Loo LWM
PROVIDER: S-EPMC6530987 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
MDM2, MDM2-C, and mutant p53 expression influence breast cancer survival in a multiethnic population.
Loo Lenora W M LWM Gao Chong C Shvetsov Yurii B YB Okoro Danielle R DR Hernandez Brenda Y BY Bargonetti Jill J
Breast cancer research and treatment 20181123 1
<h4>Purpose</h4>The purpose of the study was to examine the association between expression of mutant p53 (mtp53), full-length MDM2 (MDM2), and MDM2 isoform C (MDM2-C) and survival in multiethnic breast cancer patients.<h4>Methods</h4>A total of 787 invasive breast tumors included in a clinically annotated multiethnic population-based tissue microarray (TMA) were screened utilizing commercially available antibodies to p53 and MDM2, and a newly developed monoclonal antibody recognizing MDM2-C.<h4> ...[more]
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