The clinical outcomes of selenium supplementation on critically ill patients: A meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

Selenium supplementation is a potentially promising adjunctive therapy for critically ill patients, but the results are controversy among studies. Accordingly, we performed this meta-analysis to more clearly detect the efficacy and safety of selenium supplementation on critically ill patients.

Methods

Systematic literature retrieval was carried out to obtain RCTs on selenium supplementation for critically ill patients up to August 2017. Data extraction and quality evaluation of these studies were performed by 2 investigators. Statistical analyses was performed by RevMan 5.3. Trial sequential analysis (TSA) was conducted to control the risks of type I and type II errors and calculate required information size (RIS).

Results

Totally 19 RCTs involving 3341 critic

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6531101 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature