Ontology highlight
ABSTRACT:
SUBMITTER: Abello J
PROVIDER: S-EPMC6531310 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Abello Javier J Nguyen Tuyen Duong Thanh TDT Marasini Ramesh R Aryal Santosh S Weiss Mark Louis ML
Theranostics 20190412 8
We speculate that exosomes derived from human umbilical cord mesenchymal stromal cells (HUC-MSCs) will accumulate within tumors and have the potential for both tumor location or drug delivery. <b>Methods</b>: To determine proof of concept, HUC-MSC exosomes were labeled with an MRI contrast agent, gadolinium, or a near infrared dye. Exosome accumulation within ectopic osteosarcoma tumor-bearing mice was determined by 14.1 T MRI or bioimaging over 24-48 h after injection. <i>In vitro</i> studies e ...[more]