Ontology highlight
ABSTRACT:
SUBMITTER: Meixiong J
PROVIDER: S-EPMC6531358 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Meixiong James J Anderson Michael M Limjunyawong Nathachit N Sabbagh Mark F MF Hu Eric E Mack Madison R MR Oetjen Landon K LK Wang Fang F Kim Brian S BS Dong Xinzhong X
Immunity 20190423 5
Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation and histamine release. Recently, members of the Mas-related G-protein-coupled receptor (Mrgpr) family have been identified as mast cell receptors, but their role in itch is unclear. Here, we report that mast cell activation via Mrgprb2 evoked non-histaminergic itch in mice independently of the IgE-Fc epsilon RI (FcεRI)-histamine axis. Compared with IgE-FcεRI stimulation, Mrgprb2 activation of mast cells w ...[more]