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Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial.


ABSTRACT: Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were randomly assigned to a 3-month intervention, involving a face-to-face meeting (a medication review and a consumer-centred video) and health coaching every two weeks. Thirty-six were randomised to receive usual care. All participants were followed for nine months post-intervention. There were no differences in adherence between groups measured by Medication Event Monitoring System (MEMS), however, it was underutilised by 42% of participants. Based on the self-reported Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©) score, the percentage of adherent participants decreased significantly between baseline and 3 to 12 months in the control group (p-values?

SUBMITTER: Low JK 

PROVIDER: S-EPMC6531445 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial.

Low Jac Kee JK   Manias Elizabeth E   Crawford Kimberley K   Walker Rowan R   Mulley William R WR   Toussaint Nigel D ND   Dooley Michael M   Kennedy Elaine E   Smith Catherine L CL   Nalder Michelle M   Yip Doris D   Williams Allison A  

Scientific reports 20190522 1


Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were  ...[more]

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