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Development of pink-beam 4D phase CT for in-situ observation of polymers under infrared laser irradiation.

ABSTRACT: Four-dimensional phase computed tomography (4D phase CT) by an X-ray Talbot interferometer (XTI) with white synchrotron radiation has ever been demonstrated at a temporal resolution of about 1?s for soft-matter samples. However, the radiation damage to samples caused by white synchrotron radiation occasionally hampers our understanding of the sample dynamical properties. Based on the fact that XTI functions with X-rays of a bandwidth up to ca. 10% with performance comparable to that by monochromatic X-rays, filtering white synchrotron radiation to generate a 'pink-beam' of a 10% bandwidth is effective to reduce radiation damage without degrading the image quality and temporal resolution. We have therefore developed pink-beam 4D phase CT at SPring-8, Japan by installing a multilayer mirror with a 10% bandwidth and a 25?keV central photon energy. XTI optimal at this photon energy was built downstream, and a CMOS-based X-ray detector was used to achieve fast image acquisitions with an exposure time of 1?ms (or 0.5?ms) per moiré image. The resultant temporal resolution of pink-beam 4D phase CT was 2?s (1?s). We applied the pink-beam 4D phase CT to in-situ observation of polypropylene, poly(methyl methacrylate), and polycarbonate under infrared laser irradiation (1064?nm). The dynamics of melting, bubbling, and ashing were successfully visualized in 3D movies without problematic radiation damage by synchrotron radiation.

SUBMITTER: Vegso K

PROVIDER: S-EPMC6531456 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Development of pink-beam 4D phase CT for in-situ observation of polymers under infrared laser irradiation.

Vegso Karol K Wu Yanlin Y Takano Hidekazu H Hoshino Masato M Momose Atsushi A

Scientific reports 20190522 1

Four-dimensional phase computed tomography (4D phase CT) by an X-ray Talbot interferometer (XTI) with white synchrotron radiation has ever been demonstrated at a temporal resolution of about 1 s for soft-matter samples. However, the radiation damage to samples caused by white synchrotron radiation occasionally hampers our understanding of the sample dynamical properties. Based on the fact that XTI functions with X-rays of a bandwidth up to ca. 10% with performance comparable to that by monochrom ...[more]

PMID: 31118428

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Project description:PurposeCurrently, four-dimensional (4D) cone-beam computed tomography (CBCT) requires a 3-4 min full-fan scan to ensure usable image quality. Recent advancements in sparse-view 4D-CBCT reconstruction have opened the possibility to reduce scan time and dose. The aim of this study is to provide a common framework for systematically evaluating algorithms for 4D-CBCT reconstruction from a 1-min scan. Using this framework, the AAPM-sponsored SPARE Challenge was conducted in 2018 to identify and compare state-of-the-art algorithms.MethodsA clinically realistic CBCT dataset was simulated using patient CT volumes from the 4D-Lung database. The selected patients had multiple 4D-CT sessions, where the first 4D-CT was used as the prior CT, and the rest were used as the ground truth volumes for simulating CBCT projections. A GPU-based Monte Carlo tool was used to simulate the primary, scatter, and quantum noise signals. A total of 32 CBCT scans of nine patients were generated. Additional qualitative analysis was performed on a clinical Varian and clinical Elekta dataset to validate the simulation study. Participants were blinded from the ground truth, and were given 3 months to apply their reconstruction algorithms to the projection data. The submitted reconstructions were analyzed in terms of root-mean-squared-error (RMSE) and structural similarity index (SSIM) with the ground truth within four different region-of-interests (ROI) - patient body, lungs, planning target volume (PTV), and bony anatomy. Geometric accuracy was quantified as the alignment error of the PTV.ResultsTwenty teams participated in the challenge, with five teams completing the challenge. Techniques involved in the five methods included iterative optimization, motion-compensation, and deformation of the prior 4D-CT. All five methods rendered significant reduction in noise and streaking artifacts when compared to the conventional Feldkamp-Davis-Kress (FDK) algorithm. The RMS of the three-dimensional (3D) target registration error of the five methods ranged from 1.79 to 3.00 mm. Qualitative observations from the Varian and Elekta datasets mostly concur with those from the simulation dataset. Each of the methods was found to have its own strengths and weaknesses. Overall, the MA-ROOSTER method, which utilizes a 4D-CT motion model for temporal regularization, had the best and most consistent image quality and accuracy.ConclusionThe SPARE Challenge represents the first framework for systematically evaluating state-of-the-art algorithms for 4D-CBCT reconstruction from a 1-min scan. Results suggest the potential for reducing scan time and dose for 4D-CBCT. The challenge dataset and analysis framework are publicly available for benchmarking future reconstruction algorithms.

Dataset Information

Development of pink-beam 4D phase CT for in-situ observation of polymers under infrared laser irradiation.

Publications

Development of pink-beam 4D phase CT for in-situ observation of polymers under infrared laser irradiation.

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