Ontology highlight
ABSTRACT:
SUBMITTER: Vachon CM
PROVIDER: S-EPMC6532188 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Vachon Celine M CM Scott Christopher G CG Tamimi Rulla M RM Thompson Deborah J DJ Fasching Peter A PA Stone Jennifer J Southey Melissa C MC Winham Stacey S Lindström Sara S Lilyquist Jenna J Giles Graham G GG Milne Roger L RL MacInnis Robert J RJ Baglietto Laura L Li Jingmei J Czene Kamila K Bolla Manjeet K MK Wang Qin Q Dennis Joe J Haeberle Lothar L Eriksson Mikael M Kraft Peter P Luben Robert R Wareham Nick N Olson Janet E JE Norman Aaron A Polley Eric C EC Maskarinec Gertraud G Le Marchand Loic L Haiman Christopher A CA Hopper John L JL Couch Fergus J FJ Easton Douglas F DF Hall Per P Chatterjee Nilanjan N Garcia-Closas Montse M
Breast cancer research : BCR 20190522 1
<h4>Background</h4>Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important to more accurately predict risk.<h4>Methods</h4>Using 3628 breast cancer cases and 5126 controls of European ancestry from eight case-control studies, we evaluated joint associations of a 77-si ...[more]