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A genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis.

ABSTRACT: BACKGROUND:Human milk oligosaccharides (OS) play a key role in brain and gut microbiota development of the neonate, but the underlying biosynthetic steps of OS in the mammary gland are still largely unknown. As bovine milk contains OS with somewhat similar structures and functionalities there is increased interest in further understanding the genetic basis underlying the OS content of milk for eventual extraction and generation of value-added ingredients for infant formulas and nutraceuticals. The present study is the first to report on genetic parameter estimation as well as on a genome wide association study (GWAS) from the largest bovine milk OS dataset analyzed to date. RESULTS:In total 15 different bovine milk OS were monitored. Heritabilities ranged from 0 to 0.68 in Danish Holstein and from 0 to 0.92 in Danish Jersey. The GWAS identified in total 1770 SNPs (FDR?

SUBMITTER: Poulsen NA

PROVIDER: S-EPMC6532250 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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A genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis.

Poulsen Nina A NA Robinson Randall C RC Barile Daniela D Larsen Lotte B LB Buitenhuis Bart B

BMC genomics 20190522 1

<h4>Background</h4>Human milk oligosaccharides (OS) play a key role in brain and gut microbiota development of the neonate, but the underlying biosynthetic steps of OS in the mammary gland are still largely unknown. As bovine milk contains OS with somewhat similar structures and functionalities there is increased interest in further understanding the genetic basis underlying the OS content of milk for eventual extraction and generation of value-added ingredients for infant formulas and nutraceut ...[more]

PMID: 31117955

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