Dataset Information

Performance of Omnipod Personalized Model Predictive Control Algorithm with Moderate Intensity Exercise in Adults with Type 1 Diabetes.

ABSTRACT: Background: The objective of this study was to assess the safety and performance of the Omnipod® personalized model predictive control (MPC) algorithm with variable glucose setpoints and moderate intensity exercise using an investigational device in adults with type 1 diabetes (T1D). Materials and Methods: A supervised 54-h hybrid closed-loop (HCL) study was conducted in a hotel setting after a 7-day outpatient standard treatment phase. Adults aged 18-65 years with T1D and HbA1c between 6.0% and 10.0% were eligible. Subjects completed two moderate intensity exercise sessions of >30?min duration on consecutive days: the first with the glucose set point increased from 130 to 150?mg/dL and the second with a temporary basal rate of 50%, both started 90?min pre-exercise. Primary endpoints were percentage time in hypoglycemia <70?mg/dL and hyperglycemia ?250?mg/dL. Results: Twelve subjects participated in the study, with (mean?±?standard deviation) age 36.5?±?14.4 years, diabetes duration 21.7?±?15.7 years, HbA1c 7.6%?±?1.1%, and total daily dose 0.60?±?0.22?U/kg. Outcomes for the 54-h HCL period were mean glucose: 136?±?14?mg/dL, percentage time <70?mg/dL: 1.4%?±?1.3%, 70-180?mg/dL: 85.1%?±?9.3%, and ?250?mg/dL: 1.8%?±?2.4%. In the 12-h period after exercise start, percentage time <70?mg/dL was 1.4%?±?2.7% with the raised glucose set point and 1.6%?±?3.0% with reduced basal rate. The percentage time <70?mg/dL overnight was 0%?±?0% on both study nights. Conclusions: The Omnipod personalized MPC algorithm performed well and was safe during day and night use in response to variable glucose set points and with temporarily raised glucose set point or reduced basal rate 90?min in advance of moderate intensity exercise in adults with T1D.

SUBMITTER: Forlenza GP

PROVIDER: S-EPMC6532546 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Performance of Omnipod Personalized Model Predictive Control Algorithm with Moderate Intensity Exercise in Adults with Type 1 Diabetes.

Forlenza Gregory P GP Buckingham Bruce A BA Christiansen Mark P MP Wadwa R Paul RP Peyser Thomas A TA Lee Joon Bok JB O'Connor Jason J Dassau Eyal E Huyett Lauren M LM Layne Jennifer E JE Ly Trang T TT

Diabetes technology & therapeutics 20190329 5

Background: The objective of this study was to assess the safety and performance of the Omnipod® personalized model predictive control (MPC) algorithm with variable glucose setpoints and moderate intensity exercise using an investigational device in adults with type 1 diabetes (T1D). Materials and Methods: A supervised 54-h hybrid closed-loop (HCL) study was conducted in a hotel setting after a 7-day outpatient standard treatment phase. Adults aged 18-65 ye ...[more]

PMID: 30925077

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Project description:AIMS/HYPOTHESIS: Exercise represents an effective interventional strategy to improve glycaemic control in type 2 diabetes patients. However, the impact of exercise intensity on the benefits of exercise training remains to be established. In the present study, we compared the clinical benefits of 6 months of continuous low- to moderate-intensity exercise training with those of continuous moderate- to high-intensity exercise training, matched for energy expenditure, in obese type 2 diabetes patients. METHODS: Fifty male obese type 2 diabetes patients (age 59 +/- 8 years, BMI 32 +/- 4 kg/m(2)) participated in a 6 month continuous endurance-type exercise training programme. All participants performed three supervised exercise sessions per week, either 55 min at 50% of whole body peak oxygen uptake (VO(2)peak (low to moderate intensity) or 40 min at 75% of VO(2)peak (moderate to high intensity). Oral glucose tolerance, blood glycated haemoglobin, lipid profile, body composition, maximal workload capacity, whole body and skeletal muscle oxidative capacity and skeletal muscle fibre type composition were assessed before and after 2 and 6 months of intervention. RESULTS: The entire 6 month intervention programme was completed by 37 participants. Continuous endurance-type exercise training reduced blood glycated haemoglobin levels, LDL-cholesterol concentrations, body weight and leg fat mass, and increased VO(2)peak, lean muscle mass and skeletal muscle cytochrome c oxidase and citrate synthase activity (p < 0.05). No differences were observed between the groups training at low to moderate or moderate to high intensity. CONCLUSIONS/INTERPRETATION: When matched for energy cost, prolonged continuous low- to moderate-intensity endurance-type exercise training is equally effective as continuous moderate- to high-intensity training in lowering blood glycated haemoglobin and increasing whole body and skeletal muscle oxidative capacity in obese type 2 diabetes patients. TRIAL REGISTRATION: ISRCTN32206301 FUNDING: None.

Dataset Information

Performance of Omnipod Personalized Model Predictive Control Algorithm with Moderate Intensity Exercise in Adults with Type 1 Diabetes.

Publications

Performance of Omnipod Personalized Model Predictive Control Algorithm with Moderate Intensity Exercise in Adults with Type 1 Diabetes.

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