Is risk-stratified breast cancer screening economically efficient in Germany?

ABSTRACT:

Objectives

Risk stratification has so far been evaluated under the assumption that women fully adhere to screening recommendations. However, the participation in German cancer screening programs remains low at 54%. The question arises whether risk-stratified screening is economically efficient under the assumption that adherence is not perfect.

Method

We have adapted a micro-simulation Markov model to the German context. Annual, biennial, and triennial routine screening are compared with five risk-adapted strategies using thresholds of relative risk to stratify screening frequencies. We used three outcome variables (mortality reduction, quality-adjusted life years, and false-positive results) under the assumption of full adherence vs. an adherence rate of 54%. Strategies are

SUBMITTER: Arnold M 

PROVIDER: S-EPMC6532918 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature