Ontology highlight
ABSTRACT:
SUBMITTER: Vaz F
PROVIDER: S-EPMC6533200 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Vaz Filipa F Kounatidis Ilias I Covas Gonçalo G Parton Richard M RM Harkiolaki Maria M Davis Ilan I Filipe Sergio Raposo SR Ligoxygakis Petros P
Cell reports 20190501 8
In Drosophila, it is thought that peptidoglycan recognition proteins (PGRPs) SA and LC structurally discriminate between bacterial peptidoglycans with lysine (Lys) or diaminopimelic (DAP) acid, respectively, thus inducing differential antimicrobial transcription response. Here, we find that accessibility to PG at the cell wall plays a central role in immunity to infection. When wall teichoic acids (WTAs) are genetically removed from S. aureus (Lys type) and Bacillus subtilis (DAP type), thus inc ...[more]