Instant kit preparation of ⁶⁸Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [⁶⁸Ga]Ga-DATA-TOC.

ABSTRACT:

Purpose

The widespread use of ⁶⁸Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The DATA (6-amino-1,4-diazapine-triacetate) scaffold represents a novel hybrid chelator architecture possessing both cyclic and acyclic character that may allow for facile access to ⁶⁸Ga-labelled tracers in the clinic. We report the first bifunctional DATA chelator conjugated to [Tyr³]octreotide (TOC), a somatostatin subtype 2 receptor (SST₂)-targeting vector for imaging and functional characterisation of SSTR₂ expressing tumours.

Methods

The radiopharmaceutical precursor, DATA-TOC, was synthesised as previo

SUBMITTER: Sinnes JP 

PROVIDER: S-EPMC6533321 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature