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Increased salivary microvesicles are associated with the prognosis of patients with oral squamous cell carcinoma.


ABSTRACT: Microvesicles (MVs), which are cell-derived membrane vesicles present in body fluids, are closely associated with the development of malignant tumours. Saliva, one of the most versatile body fluids, is an important source of MVs. However, the association between salivary MVs (SMVs) and oral squamous cell carcinoma (OSCC), which is directly immersed in the salivary milieu, remains unclear. SMVs from 65 patients with OSCC, 21 patients with oral ulcer (OU), and 42 healthy donors were purified, quantified and analysed for their correlations with the clinicopathologic features and prognosis of OSCC patients. The results showed that the level of SMVs was significantly elevated in patients with OSCC compared to healthy donors and OU patients. Meanwhile, the level of SMVs showed close correlations with the lymph node status, and the clinical stage of OSCC patients. Additionally, the ratio of apoptotic to non-apoptotic SMVs was significantly decreased in OSCC patients with higher pathological grade. Consistently, poorer overall survival was observed in patients with lower ratio of apoptotic to non-apoptotic SMVs. In conclusion, the elevated level of SMVs is associated with clinicopathologic features and decreased survival in patients with OSCC, suggesting that SMVs are a potential biomarker and/or regulator of the malignant progression of OSCC.

SUBMITTER: Zhong WQ 

PROVIDER: S-EPMC6533497 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Increased salivary microvesicles are associated with the prognosis of patients with oral squamous cell carcinoma.

Zhong Wen-Qun WQ   Ren Jian-Gang JG   Xiong Xue-Peng XP   Man Qi-Wen QW   Zhang Wei W   Gao Lu L   Li Chen C   Liu Bing B   Sun Zhi-Jun ZJ   Jia Jun J   Zhang Wen-Feng WF   Zhao Yi-Fang YF   Chen Gang G  

Journal of cellular and molecular medicine 20190325 6


Microvesicles (MVs), which are cell-derived membrane vesicles present in body fluids, are closely associated with the development of malignant tumours. Saliva, one of the most versatile body fluids, is an important source of MVs. However, the association between salivary MVs (SMVs) and oral squamous cell carcinoma (OSCC), which is directly immersed in the salivary milieu, remains unclear. SMVs from 65 patients with OSCC, 21 patients with oral ulcer (OU), and 42 healthy donors were purified, quan  ...[more]

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