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ABSTRACT: Background
Prediabetes appears to be increasing worldwide. This study examined the incidence of prediabetes among immigrants to Canada of different ethnic origins and the age at which ethnic differences emerged.Methods
We assembled a cohort of Ontario adults (??20?years) with normoglycemia based on glucose testing performed between 2002 and 2011 through a single commercial laboratory database (N?=?1,772,180). Immigration data were used to assign ethnicity based on country of origin, mother tongue, and surname. Individuals were followed until December 2013 for the development of prediabetes, defined using either the World Health Organization/Diabetes Canada (WHO/DC) or American Diabetes Association (ADA) thresholds. Multivariate competing risk regression models were derived to examine the effect of ethnicity and immigration status on prediabetes incidence.Results
After a median follow-up of 8.0?years, 337,608 individuals developed prediabetes. Using definitions based on WHO/DC, the adjusted cumulative incidence of prediabetes was 40% (HR 1.40, CI 1.38-1.41) higher for immigrants relative to long-term Canadian residents (21.2% vs 16.0%, p?ConclusionPrediabetes incidence was substantially higher among non-European immigrants to Canada, highlighting the need for early prevention strategies in these populations.
SUBMITTER: Fazli GS
PROVIDER: S-EPMC6533737 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Fazli Ghazal S GS Moineddin Rahim R Bierman Arlene S AS Booth Gillian L GL
BMC medicine 20190523 1
<h4>Background</h4>Prediabetes appears to be increasing worldwide. This study examined the incidence of prediabetes among immigrants to Canada of different ethnic origins and the age at which ethnic differences emerged.<h4>Methods</h4>We assembled a cohort of Ontario adults (≥ 20 years) with normoglycemia based on glucose testing performed between 2002 and 2011 through a single commercial laboratory database (N = 1,772,180). Immigration data were used to assign ethnicity based on country of orig ...[more]