Antidepressant-like effect of a standardized hydroethanolic extract of Asparagus adscendens in mice.

ABSTRACT:

Objective

Asparagus adscendens Roxb. (Liliaceae), a traditional herbal medicine, has been used as an aphrodisiac and brain tonic in Asian countries. The aim of the present study is to investigate the antidepressant-like effect of standardized hydroethanolic extract of A. adscendens root and its possible mechanisms.

Materials and methods

Mice administered with vehicle, imipramine (15 mg/kg/day; i.p.), and A. adscendens extract (AAE) (25, 50, and 100 mg/kg/day; i.p.) for 14 days were subjected to behavioral tests including forced swimming test (FST), tail suspension test (TST), and open-field test (OFT) on the 14^th day. In order to explore the underlying mechanism behind an antidepressant effect of AAE, the brain monoamine levels, oxidative stre

SUBMITTER: Pahwa P 

PROVIDER: S-EPMC6533926 | biostudies-literature | 2019 Mar-Apr

REPOSITORIES: biostudies-literature