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Effect of conversion from calcineurin inhibitors to everolimus on hepatitis C viremia in adult kidney transplant recipients.


ABSTRACT: INTRODUCTION:Currently, there is no specific immunosuppressive protocol for hepatitis C (HCV)-positive renal transplants recipients. Thus, the aim of this study was to evaluate the conversion effect to everolimus (EVR) on HCV in adult kidney recipients. METHOD:This is an exploratory single-center, prospective, randomized, open label controlled trial with renal allograft recipients with HCV-positive serology. Participants were randomized for conversion to EVR or maintenance of calcineurin inhibitors. RESULTS:Thirty patients were randomized and 28 were followed-up for 12 months (conversion group, Group 1 =15 and control group, Group 2 =13). RT-PCR HCV levels reported in log values were comparable in both groups and among patients in the same group. The statistical analysis showed no interaction effect between time and group (p value G*M= 0.852), overtime intra-groups (p-value M=0.889) and between group (p-value G=0.286). Group 1 showed a higher incidence of dyslipidemia (p=0.03) and proteinuria events (p=0.01), while no difference was observed in the incidence of anemia (p=0.17), new onset of post-transplant diabetes mellitus (p=1.00) or urinary tract infection (p=0.60). The mean eGFR was similar in both groups. CONCLUSION:Our study did not show viral load decrease after conversion to EVR with maintenance of antiproliferative therapy.

SUBMITTER: Pacheco LS 

PROVIDER: S-EPMC6533980 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature

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Effect of conversion from calcineurin inhibitors to everolimus on hepatitis C viremia in adult kidney transplant recipients.

Pacheco Larissa Sgaria LS   Garcia Valter Duro VD   Prá Ronivan Luis Dal RLD   Cardoso Bruna Doleys BD   Rodrigues Mariana Ferras MF   Zanetti Helen Kris HK   Meinerz Gisele G   Neumann Jorge J   Gnatta Diego D   Keitel Elizete E  

Jornal brasileiro de nefrologia 20180401 2


<h4>Introduction</h4>Currently, there is no specific immunosuppressive protocol for hepatitis C (HCV)-positive renal transplants recipients. Thus, the aim of this study was to evaluate the conversion effect to everolimus (EVR) on HCV in adult kidney recipients.<h4>Method</h4>This is an exploratory single-center, prospective, randomized, open label controlled trial with renal allograft recipients with HCV-positive serology. Participants were randomized for conversion to EVR or maintenance of calc  ...[more]

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