DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection.
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ABSTRACT:
SUBMITTER: Mathur R
PROVIDER: S-EPMC6534194 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection.
Mathur Raina R Hui Qin Q Huang Yunfeng Y Gwinn Marta M So-Armah Kaku K Freiberg Matthew S MS Justice Amy C AC Xu Ke K Marconi Vincent C VC Sun Yan V YV
The Journal of infectious diseases 20190501 12
Epigenetic modifications such as DNA methylation are associated with both human immunodeficiency virus (HIV) infection and type 2 diabetes mellitus (T2DM). We investigated epigenetic associations with T2DM according to HIV infection status and assessed interaction effects among 681 male participants of the Veterans Aging Cohort Study. Methylation at previously reported sites, cg1963031 (TXNIP), cg18181703 (SOCS3), and cg09152259 (PROC), was significantly associated with T2DM in HIV-infected indi ...[more]
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