Ontology highlight
ABSTRACT:
SUBMITTER: Dunovan K
PROVIDER: S-EPMC6534331 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Dunovan Kyle K Vich Catalina C Clapp Matthew M Verstynen Timothy T Rubin Jonathan J
PLoS computational biology 20190506 5
Cortico-basal-ganglia-thalamic (CBGT) networks are critical for adaptive decision-making, yet how changes to circuit-level properties impact cognitive algorithms remains unclear. Here we explore how dopaminergic plasticity at corticostriatal synapses alters competition between striatal pathways, impacting the evidence accumulation process during decision-making. Spike-timing dependent plasticity simulations showed that dopaminergic feedback based on rewards modified the ratio of direct and indir ...[more]