Autophagy induced by avian reovirus enhances viral replication in chickens at the early stage of infection.
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ABSTRACT:
SUBMITTER: Niu X
PROVIDER: S-EPMC6534907 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Autophagy induced by avian reovirus enhances viral replication in chickens at the early stage of infection.
Niu Xiaosai X Zhang Chengcheng C Wang Yuyang Y Guo Mengjiao M Ruan Baoyang B Wang Xuefeng X Wu Tianqi T Zhang Xiaorong X Wu Yantao Y
BMC veterinary research 20190524 1
<h4>Background</h4>Avian reovirus (ARV) is an important pathogen that can cause serious disease in poultry. Though several in vitro studies revealed some molecular mechanisms that are responsible for ARV-induced autophagy, it is still largely unknown how ARV manipulates autophagy to promote its own propagation.<h4>Results</h4>In this study, we demonstrated that ARV infection triggered autophagy in chicken tissues, evident from the enhancement of LC3-I/-II conversion and the appearance of abundan ...[more]
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