Ontology highlight
ABSTRACT:
SUBMITTER: Sarker G
PROVIDER: S-EPMC6534971 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Sarker Gitalee G Sun Wenfei W Rosenkranz David D Pelczar Pawel P Opitz Lennart L Efthymiou Vissarion V Wolfrum Christian C Peleg-Raibstein Daria D
Proceedings of the National Academy of Sciences of the United States of America 20190506 21
There is a growing body of evidence linking maternal overnutrition to obesity and psychopathology that can be conserved across multiple generations. Recently, we demonstrated in a maternal high-fat diet (HFD; MHFD) mouse model that MHFD induced enhanced hedonic behaviors and obesogenic phenotypes that were conserved across three generations via the paternal lineage, which was independent of sperm methylome changes. Here, we show that sperm tRNA-derived small RNAs (tsRNAs) partly contribute to th ...[more]