Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC6534990 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chen Zhoumou Z Doyle Timothy M TM Luongo Livio L Largent-Milnes Tally M TM Giancotti Luigino Antonio LA Giancotti Luigino Antonio LA Kolar Grant G Squillace Silvia S Boccella Serena S Walker John K JK Pendleton Alexander A Spiegel Sarah S Neumann William L WL Vanderah Todd W TW Salvemini Daniela D
Proceedings of the National Academy of Sciences of the United States of America 20190508 21
Neuropathic pain afflicts millions of individuals and represents a major health problem for which there is limited effective and safe therapy. Emerging literature links altered sphingolipid metabolism to nociceptive processing. However, the neuropharmacology of sphingolipid signaling in the central nervous system in the context of chronic pain remains largely unexplored and controversial. We now provide evidence that sphingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord i ...[more]