Ontology highlight
ABSTRACT:
SUBMITTER: Eshun-Wilson L
PROVIDER: S-EPMC6535015 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Eshun-Wilson Lisa L Zhang Rui R Portran Didier D Nachury Maxence V MV Toso Daniel B DB Löhr Thomas T Vendruscolo Michele M Bonomi Massimiliano M Fraser James S JS Nogales Eva E
Proceedings of the National Academy of Sciences of the United States of America 20190509 21
Acetylation of K40 in α-tubulin is the sole posttranslational modification to mark the luminal surface of microtubules. It is still controversial whether its relationship with microtubule stabilization is correlative or causative. We have obtained high-resolution cryo-electron microscopy (cryo-EM) reconstructions of pure samples of αTAT1-acetylated and SIRT2-deacetylated microtubules to visualize the structural consequences of this modification and reveal its potential for influencing the larger ...[more]