Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR).
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6535107 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR).
Zhang Youxi Y Zhang Xinfu X Zeng Chunxi C Li Bin B Zhang Chengxiang C Li Wenqing W Hou Xucheng X Dong Yizhou Y
Bioorganic & medicinal chemistry 20190411 11
Targeted drug delivery platforms can increase the concentration of drugs in specific cell populations, reduce adverse effects, and hence improve the therapeutic effect of drugs. Herein, we designed two conjugates by installing the targeting ligand GalNAc (N-acetylgalactosamine) onto atorvastatin (AT). Compared to the parent drug, these two conjugates, termed G2-AT and G2-K-AT, showed increased hepatic cellular uptake. Moreover, both conjugates were able to release atorvastatin, and consequently ...[more]
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