Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.
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ABSTRACT:
SUBMITTER: Wang QA
PROVIDER: S-EPMC6535147 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.
Wang Qiong A QA Song Anying A Chen Wanze W Schwalie Petra C PC Zhang Fang F Vishvanath Lavanya L Jiang Lei L Ye Risheng R Shao Mengle M Tao Caroline C Gupta Rana K RK Deplancke Bart B Scherer Philipp E PE
Cell metabolism 20180614 2
Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα<sup>+</sup> preadipocyte- and fibroblast-like cells during pregnancy and re ...[more]
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